How payments to us affect ranking

Select dates to see exact prices
Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg
Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg
Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg
Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg
Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg

Good to know

  • Well-equipped 24-hour fitness center

    Maintain your workout routine with access to a fitness center featuring dumbbells, ellipticals, treadmills, and a bike.

  • Prime downtown theatre district location

    Nestled in the heart of the Theatre District, enjoy easy access to Shea's Performing Arts Center, Irish Classical Theatre, Town Ballroom, and TRALF.

  • Spacious two-room suite layouts

    Relax in expansive suites featuring a separate living room with a pull-out sofa, offering ample space and privacy for all guests.

  • Dove bath products in every room

    Indulge in quality Dove bath products provided in each room, enhancing your personal care experience.

  • In-room microwave and refrigerator

    Benefit from the convenience of a microwave and refrigerator in every room, perfect for snacks and beverages.

This summary was created by AI and might not be 100% accurate.

About Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg

A straightforward all-suite hotel, Holiday Inn Express & Suites Buffalo Downtown - Medical CTR is nestled in Downtown Buffalo. This hotel features low-key suites with sitting areas and daily housekeeping. Guests can enjoy free newspapers in the lobby. All of the 146 smoke-free guestrooms boast climate control, sofa bed, air conditioning, blackout drapes, premium TV channels, microwave, refrigerator, and work desk. The private baths offer free toiletries and hair dryer. Freebies include bottled water, Wi-Fi, and local calls. At Holiday Inn Express & Suites Buffalo Downtown - Medical CTR, guests have access to a business center, dry cleaning/laundry service, fitness facilities, 24-hour front desk, and disabled parking. Accessibility equipment for the hearing impaired are available. TGI Fridays, the on-site restaurant, features American cuisine and serves breakfast, lunch, and dinner. Refreshments are available in the bar/lounge. Coca-Cola Field and Wilcox Mansion (Theodore Roosevelt Inaugural National Historic Site) are less than a mile away. Pierce - Arrow Museum, KeyBank Center, and Buffalo and Erie County Naval and Military Park are all within a mile.

Rooms

  • Suite, 1 Bedroom, Accessible (Mobility Accessible, Bathtub)

    • 1 1 Queen Bed
    • Sleeps 4
    • 500 sq ft

  • Suite, 1 Bedroom, Accessible (Mobility Accessible, Roll-in Shower)

    • 1 1 Queen Bed
    • Sleeps 4
    • 500 sq ft

  • Standard Room

    • 1 1 King Bed and 1 Double Sofa Bed
    • Sleeps 2
    • 500 sq ft

  • Suite, 1 Bedroom

    • 1 1 King Bed
    • Sleeps 4
    • 500 sq ft

Compare with similar stays

Selected stay

  • Free WiFi
  • Parking
  • A/C
Select dates to see exact prices

Similar stays

    • Free WiFi
    • A/C
    • Hotel bar
    Select dates to see exact prices

    • Free WiFi
    • Parking
    • Pets
    from$80
    See prices from 5 sites

    • Free WiFi
    • Pool
    • Parking
    Select dates to see exact prices

    • Free WiFi
    • Pool
    • Pets
    Select dates to see exact prices

    • Free WiFi
    • Pool
    • Parking
    Select dates to see exact prices

    • Free WiFi
    • Pool
    • Parking
    Select dates to see exact prices

    • Free WiFi
    • Spa
    • Parking
    Select dates to see exact prices

    • Free WiFi
    • Parking
    • Pets
    Select dates to see exact prices

    • Free WiFi
    • Pool
    • Pets
    Select dates to see exact prices

    • Free WiFi
    • Parking
    • A/C
    Select dates to see exact prices

    • Free WiFi
    • Parking
    • Pets
    Select dates to see exact prices

Reviews

8.3
Very good
based on 4,846 ratings from top 
sites

Review summary

Summarized by AI from 900+ reviews · Last updated: 30 Jul 2026

This hotel is a versatile urban hub catering equally to sightseers and business travelers, offering a comfortable and convenient base for exploring the city. Its excellent location in the heart of downtown Buffalo places guests within walking distance of major attractions like Shea's Theater and the KeyBank Center, with a metro station directly across the street for easy access to further destinations. The complimentary breakfast, featuring a wide variety of hot and cold options, and the convenience of an on-site TGI Fridays restaurant, cater to diverse dining preferences. Guests consistently praise the reception team for their efficiency and helpfulness, ensuring a smooth and pleasant stay. For a quieter experience, guests should consider requesting a room on a higher floor or facing away from Main Street.

Rated above average for Buffalo

Guest reviews

Excellent32%
Very good52%
Good7%
Fair4%
Poor5%

Top amenities

  • WiFi in lobby
  • WiFi in rooms
  • Parking
  • A/C
  • Gym

All amenities

Property amenities

  1. Business center
  2. Entrance hall/lobby
  3. Express check-in/check-out
  4. Lift
  5. Gym
  6. Parking
  7. Non-smoking rooms
  8. 24-hour reception
  9. Laundry service
  10. Fax/Modem access
  11. Car hire
  12. Free WiFi in public areas

For children

  1. Cot

Accessibility

  1. Wheelchair accessible
  2. Accessible travel path
  3. Accessible parking

Room amenities

  1. Bathtub
  2. Shower
  3. Ironing board
  4. Television
  5. Hairdryer
  6. Central heating
  7. Air conditioning
  8. Radio
  9. Satellite TV
  10. Desk
  11. Telephone
  12. Room safe

Sports facilities

  1. Fitness

Hotel theme/type

  1. Airport hotel

Location

601 Main St, Buffalo, 14203, USA

Distance from Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg

Fountain Plaza:0.1 km

Buffalo:0.6 km

Sahlen Field:1.1 km

Theodore Roosevelt Inaugural National Historic Site:1.2 km

USS Croaker:1.5 km

USS The Sullivans:1.6 km

USS Little Rock:1.6 km

KeyBank Center:1.7 km

Old Fort Erie:4.2 km

Darwin D. Martin House:5.5 km

Buffalo-Niagara International Airport:12.8 km

UB Stadium:14.4 km

Explore nearby attractions

Property info

601 Main St, Buffalo, 14203, USA

Frequently Asked Questions about Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg

  • Is there a pool area at Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg?

    No, Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg doesn’t offer pool areas.

  • Are pets allowed at Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg?

    No, Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg doesn’t allow pets.

  • Is parking available at Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg?

    Yes, Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg provides Parking, Accessible parking for guests.

  • What time is check-in and check-out at Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg?

    Check-in at Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg is available from: . Check-out time is by .

  • Where is Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg located?

    Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg is located at 601 Main St, 14203, Buffalo, USA.

The prices and availability we receive from booking sites change constantly. This means you may not always find the exact same offer you saw on trivago when you land on the booking site.

Among Top Rated Hotels in Buffalo

  • Popular choice
    Embassy Suites Buffalo
    Select dates to see exact prices
  • Lenox Hotel and Suites
    Select dates to see exact prices
  • Popular choice
    Curtiss Hotel, an Ascend Collection Hotel
    Select dates to see exact prices
  • Hotel at the Lafayette Trademark Collection by Wyndham
    Select dates to see exact prices
  • Econo Lodge Buffalo South
    Select dates to see exact prices
  • Tru by Hilton Williamsville Buffalo Airport
    Select dates to see exact prices
  • Hampton Inn Buffalo South/I-90
    Select dates to see exact prices
  • Hampton Inn & Suites Buffalo Downtown
    Select dates to see exact prices
  • The Edward Hotel
    Select dates to see exact prices

Other stays in Buffalo

Popular hotel categories in Buffalo

Destinations near Holiday Inn Express & Suites Buffalo Downtown - Medical Ctr By Ihg

See all stays in Buffalo